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In addition to the WMA Declaration of Helsinki, all experiments also conformed to the principles set out in the Department of Health and Human Services Belmont Report

The peptide was shown to attenuate collagen breakdown by inhibiting procollagen-C proteinase, which cleaves the C-propeptide from type I procollagen

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Because IGF-1 LR3 has no FDA pathway and is sold only as a "research chemical," there is no mandatory COA standard, no USP monograph, and no enforcement of purity claims